New Drug Targets Mutant KRAS in Lung Cancer: a 30 Year Odyssey
The Ras proteins (coded by the NRAS, KRAS and HRAS genes) were discovered in 1982 and were subsequently found to be some of the most frequently mutated genes in all types of cancer. Mutant Ras proteins are oncogenes (genes that contribute to the initiation and/or progression of tumors) and are therefore obvious targets for the [...]